Table 1  Subject exclusion criteria for genetic analysis in GEOS study
Exclusion Criteria
1. Known single-gene or mitochondrial disorders recognized by a distinctive phenotype; e.g., cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS), homocystinuria, Fabry disease, or sickle cell anemia
2. Mechanical aortic or mitral valve at the time of index stroke
3. Untreated or actively treated bacterial endocarditis at the time of the index stroke
4. Neurosyphilis or other CNS infections
5. Neurosarcoidosis
6. Severe sepsis with hypotension at the time of the index stroke
7. Cerebral vasculitis by angiogram and clinical criteria
8. Post-radiation arteriopathy
9. Left atrial myxoma
10. Major congenital heart disease
11. Cocaine use in the 48 hr prior to the index stroke