Table 5  Loss of duplicate genes from the ancient whole-genome duplication in the Saccharomyces sensu stricto clade
S. cerevisiae Gene(s)YGOB LocusRetention PatternaFunctional Annotation
YCL048W-A / YDR524C-BAnc_1.222:1:1:1:2Uncharacterized
YFR017C / YOL024WAnc_1.3632:2:1:2:2Predicted to have thiol-disulfide oxidoreductase active site
ECM10/SSC1Anc_1.4742:2:1:2:2Hsp70 family; localized in mitochondrial nucleoids; plays a role in protein translocation
GAL80Anc_1.5001:1:1:1:2Inhibits transcriptional activation by Gal4p
HEK2Anc_3.3181:1:1/ψ:2:2RNA binding protein with similarity to hnRNP-K; localizes to the cytoplasm and subtelomeric DNA
PMT4Anc_4.3791:1:1:1:2Protein amino acid O-linked glycosylation
SLT2 / YKL161CAnc_5.2742:2:1:2:2Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity
CAD1/YAP1Anc_5.5282:2:2:2:1AP-1-like basic leucine zipper (bZIP) transcriptional activator involved in stress responses, iron metabolism, and pleiotropic drug resistance
YDR066C / YER139CAnc_8.1812:2:2:1:2Uncharacterized
SSU1Anc_8.5691:2:1:1:1Plasma membrane sulfite pump
ARL1Anc_8.5971/ψ:1/ψ:1:1/ψ:2Soluble GTPase with a role in regulation of membrane traffic
URA5/URA10Anc_8.8272:2:1:2:2Phosphoribosyltransferase; fifth step in pyrimidine biosynthesis pathway
  • a Number of detected copies or pseudogenes (ψ) in S. cerevisiae, S. paradoxus, S. mikatae, S. kudriavzevii, and S. bayanus, respectively.