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G3: Genes | Genomes | Genetics

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Research ArticleInvestigation
Open Access

Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients

A. Dessa Sadovnick, Anthony L. Traboulsee, Cecily Q. Bernales, Jay P. Ross, Amanda L. Forwell, Irene M. Yee, Lena Guillot-Noel, Bertrand Fontaine, Isabelle Cournu-Rebeix, Antonio Alcina, Maria Fedetz, Guillermo Izquierdo, Fuencisla Matesanz, Kelly Hilven, Bénédicte Dubois, An Goris, Ianire Astobiza, Iraide Alloza, Alfredo Antigüedad, Koen Vandenbroeck, Denis A. Akkad, Orhan Aktas, Paul Blaschke, Mathias Buttmann, Andrew Chan, Joerg T. Epplen, Lisa-Ann Gerdes, Antje Kroner, Christian Kubisch, Tania Kümpfel, Peter Lohse, Peter Rieckmann, Uwe K. Zettl, Frauke Zipp, Lars Bertram, Christina M. Lill, Oscar Fernandez, Patricia Urbaneja, Laura Leyva, Jose Carlos Alvarez-Cermeño, Rafael Arroyo, Aroa M. Garagorri, Angel García-Martínez, Luisa M. Villar, Elena Urcelay, Sunny Malhotra, Xavier Montalban, Manuel Comabella, Thomas Berger, Franz Fazekas, Markus Reindl, Mascha C. Schmied, Alexander Zimprich and Carles Vilarino-Guell
G3: Genes, Genomes, Genetics May 2016, g3.116.030841; DOI: https://doi.org/10.1534/g3.116.030841
A. Dessa Sadovnick
University of British Columbia;
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Anthony L. Traboulsee
University of British Columbia;
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Cecily Q. Bernales
University of British Columbia;
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Jay P. Ross
University of British Columbia;
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Amanda L. Forwell
University of British Columbia;
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Irene M. Yee
University of British Columbia;
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Lena Guillot-Noel
CNRS UMR 7225, Sorbonne Universités;
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Bertrand Fontaine
CNRS UMR 7225, Sorbonne Universités;
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Isabelle Cournu-Rebeix
CNRS UMR 7225, Sorbonne Universités;
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Antonio Alcina
Instituto de Parasitología y Biomedicina Lípez Neyra (IPBLN);
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Maria Fedetz
Hospital Universitario Virgen Macarena;
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Guillermo Izquierdo
Hospital Universitario Virgen Macarena;
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Fuencisla Matesanz
Instituto de Parasitología y Biomedicina Lípez Neyra (IPBLN);
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Kelly Hilven
KU Leuven, University of Leuven;
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Bénédicte Dubois
KU Leuven, University of Leuven;
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An Goris
KU Leuven, University of Leuven;
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Ianire Astobiza
Universidad del País Vasco;
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Iraide Alloza
Universidad del País Vasco;
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Alfredo Antigüedad
Hospital Universitario Basurto-Osakidetza;
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Koen Vandenbroeck
Universidad del País Vasco; Achucarro Basque Center for Neuroscience;
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Denis A. Akkad
Ruhr University;
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Orhan Aktas
Heinrich Heine University;
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Paul Blaschke
University of Rostock;
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Mathias Buttmann
University of Würzburg;
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Andrew Chan
St. Josef-Hospital, Ruhr University;
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Joerg T. Epplen
Ruhr University;
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Lisa-Ann Gerdes
Ludwig Maximilian University;
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Antje Kroner
University of Würzburg;;
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Christian Kubisch
Centre for Research in Neuroscience at McGill University;
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Tania Kümpfel
Ludwig Maximilian University;
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Peter Lohse
Ludwig Maximilian University; Institute of Laboratory Medicine and Human Genetics;
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Peter Rieckmann
University of Würzburg; Sozialstiftung Bamberg Hospital;
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Uwe K. Zettl
Centre for Research in Neuroscience at McGill University;
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Frauke Zipp
University Medical Center of the Johannes Gutenberg-University Mainz;
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Lars Bertram
University of Lübeck; Imperial College London;
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Christina M. Lill
University Medical Center of the Johannes Gutenberg-University Mainz; University of Lübeck;
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Oscar Fernandez
IBIMA-Hospital Regional Universitario de Málaga;
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Patricia Urbaneja
IBIMA-Hospital Regional Universitario de Málaga;
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Laura Leyva
IBIMA-Hospital Regional Universitario de Málaga;
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Jose Carlos Alvarez-Cermeño
Ramón y Cajal University Hospital-IRYCIS;
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Rafael Arroyo
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos-IdISSC;
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Aroa M. Garagorri
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos-IdISSC;
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Angel García-Martínez
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos-IdISSC;
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Luisa M. Villar
Ramón y Cajal University Hospital-IRYCIS;
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Elena Urcelay
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos-IdISSC;
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Sunny Malhotra
Universitat Autònoma de Barcelona;
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Xavier Montalban
Universitat Autònoma de Barcelona;
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Manuel Comabella
Universitat Autònoma de Barcelona;
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Thomas Berger
Medical University of Innsbruck;
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Franz Fazekas
Medical University of Graz;
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Markus Reindl
Medical University of Innsbruck;
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Mascha C. Schmied
Medical University of Vienna
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Alexander Zimprich
Medical University of Vienna
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Carles Vilarino-Guell
University of British Columbia;
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  • For correspondence: carles@can.ubc.ca

Supplemental Material for Sadovnick et al., 2016

Files in this Data Supplement:

  • Figure S1 - Segregation analysis of exome variants. (.pdf, 70 KB)
  • Figure S2 - Segregation analysis of PLG variants not observed in controls. (.pdf, 75 KB)
  • Table S1 - Chromosome 6q25.3-27 haplotypes carrying PLG p.G420D. (.pdf, 46 KB)
  • Table S2 - Novel and rare (MAF<0.01) missense variants shared by family A members II-1, II-4 and III-1. (.pdf, 53 KB)
  • Table S3 - Clinical features for PLG p.G420D carriers. (.pdf, 46 KB)
  • Table S4 - Logistic regression analysis for PLG-tagging SNPs. (.pdf, 43 KB)
  • Table S5 - PLG-coding variants identified in MS patients. (.pdf, 50 KB)

  View article

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