Sex (sx) determination is among the most interesting areas of study in modern genetics, with research spanning a large range of topics, including developmental mechanisms, behavior, sex chromosome biology and evolution. Modern tools provide opportunities to combine genetic and molecular approaches to study such processes in model and non-model systems. GENETICS and G3: Genes|Genomes|Genetics invite submissions to either journal that address the broad reach and complexity of the genetics of sex. The call for papers is ongoing.
A Hormone That Lost Its Receptor: Anti-Müllerian Hormone (AMH) in Zebrafish Gonad Development and Sex Determination
Yi-Lin Yan, Peter Batzel, Tom Titus, Jason Sydes, Thomas Desvignes, Ruth BreMiller, Bruce Draper, John H. Postlethwait
Genetics October 2019 213: 529-553; https://doi.org/10.1534/genetics.119.302365
Fine Mapping Using Whole-Genome Sequencing Confirms Anti-Müllerian Hormone as a Major Gene for Sex Determination in Farmed Nile Tilapia (Oreochromis niloticus L.)
Giovanna Cáceres, María E. López, María I. Cádiz, Grazyella M. Yoshida, Ana Jedlicki, Ricardo Palma-Véjares, Dante Travisany, Diego Díaz-Domínguez, Alejandro Maass, Jean P. Lhorente, Jose Soto, Diego Salas, José M. Yáñez
G3: Genes, Genomes, Genetics October 2019 9: 3213-3223; https://doi.org/10.1534/g3.119.400297
Paul M. Hime, Jeffrey T. Briggler, Joshua S. Reece, David W. Weisrock
G3: Genes, Genomes, Genetics October 2019 9: 3467-3476; https://doi.org/10.1534/g3.119.400556
Cyfip1 Haploinsufficiency Increases Compulsive-Like Behavior and Modulates Palatable Food Intake in Mice: Dependence on Cyfip2 Genetic Background, Parent-of Origin, and Sex
Richard K. Babbs, Jacob A. Beierle, Qiu T. Ruan, Julia C. Kelliher, Melanie M. Chen, Ashley X. Feng, Stacey L. Kirkpatrick, Fabiola A. Benitez, Fred A. Rodriguez, Johanne J. Pierre, Jeya Anandakumar, Vivek Kumar, Megan K. Mulligan, Camron D. Bryant
G3: Genes, Genomes, Genetics September 2019 9: 3009-3022; https://doi.org/10.1534/g3.119.400470
Experimental Introgression To Evaluate the Impact of Sex Specific Traits on Drosophila melanogaster Incipient Speciation
Jérôme Cortot, Jean-Pierre Farine, Benjamin Houot, Claude Everaerts, Jean-François Ferveur
G3: Genes, Genomes, Genetics August 2019 9: 2561-2572; https://doi.org/10.1534/g3.119.400385
Hybrid Assembly of the Genome of the Entomopathogenic Nematode Steinernema carpocapsae Identifies the X-Chromosome
Lorrayne Serra, Marissa Macchietto, Aide Macias-Muñoz, Cassandra Joan McGill, Isaryhia Maya Rodriguez, Bryan Rodriguez, Rabi Murad, Ali Mortazavi
G3: Genes, Genomes, Genetics August 2019 9: 2687-2697; https://doi.org/10.1534/g3.119.400180
Little Evidence of Antagonistic Selection in the Evolutionary Strata of Fungal Mating-Type Chromosomes (Microbotryum lychnidis-dioicae)
Anna Liza Bazzicalupo, Fantin Carpentier, Sarah Perin Otto, Tatiana Giraud
G3: Genes, Genomes, Genetics June 2019 9: 1987-1998; https://doi.org/10.1534/g3.119.400242
Identification of rfk-1, a Meiotic Driver Undergoing RNA Editing in Neurospora
Nicholas A. Rhoades, Austin M. Harvey, Dilini A. Samarajeewa, Jesper Svedberg, Aykhan Yusifov, Anna Abusharekh, Pennapa Manitchotpisit, Daren W. Brown, Kevin J. Sharp, David G. Rehard, Joshua Peters, Xavier Ostolaza-Maldonado, Jackson Stephenson, Patrick K. T. Shiu, Hanna Johannesson, Thomas M. Hammond
Genetics May 2019 212: 93-110; https://doi.org/10.1534/genetics.119.302122
Chromosome-Wide Evolution and Sex Determination in the Three-Sexed Nematode Auanema rhodensis
Sophie Tandonnet, Georgios D. Koutsovoulos, Sally Adams, Delphine Cloarec, Manish Parihar, Mark L. Blaxter, Andre Pires-daSilva
G3: Genes, Genomes, Genetics April 2019 9: 1211-1230; https://doi.org/10.1534/g3.119.0011
The mir-35 Family Links Maternal Germline Sex to Embryonic Viability in Caenorhabditis elegans
Lars Kristian Benner, Katherine Perkins Prothro, Katherine McJunkin
G3: Genes, Genomes, Genetics March 2019 9: 901-909; https://doi.org/10.1534/g3.118.200863
Sex-Specific Co-expression Networks and Sex-Biased Gene Expression in the Salmonid Brook Charr Salvelinus fontinalis
Ben J. G. Sutherland, Jenni M. Prokkola, Céline Audet, Louis Bernatchez
G3: Genes, Genomes, Genetics March 2019 9: 955-968; https://doi.org/10.1534/g3.118.200910
Modelling Sex-Specific Crossover Patterning in Arabidopsis
Andrew Lloyd, Eric Jenczewski
Genetics March 2019 211: 847-859; https://doi.org/10.1534/genetics.118.301838
Female Sex Development and Reproductive Duct Formation Depend on Wnt4a in Zebrafish
Michelle E. Kossack, Samantha K. High, Rachel E. Hopton, Yi-lin Yan, John H. Postlethwait, Bruce W. Draper
Genetics January 2019 211: 219-233; https://doi.org/10.1534/genetics.118.301620
Auxin-Mediated Sterility Induction System for Longevity and Mating Studies in Caenorhabditis elegans
Katja R. Kasimatis, Megan J. Moerdyk-Schauwecker, Patrick C. Phillips
G3: Genes, Genomes, Genetics August 2018 8: 2655-2662; https://doi.org/10.1534/g3.118.200278
An Association Mapping Framework To Account for Potential Sex Difference in Genetic Architectures
Eun Yong Kang, Cue Hyunkyu Lee, Nicholas A. Furlotte, Jong Wha J. Joo, Emrah Kostem, Noah Zaitlen, Eleazar Eskin, Buhm Han
Genetics July 2018 209: 685-698; https://doi.org/10.1534/genetics.117.300501
Sex Determination in Ceratopteris richardii Is Accompanied by Transcriptome Changes That Drive Epigenetic Reprogramming of the Young Gametophyte
Nadia M. Atallah, Olga Vitek, Federico Gaiti, Milos Tanurdzic, Jo Ann Banks
G3: Genes, Genomes, Genetics July 2018 8: 2205-2214; https://doi.org/10.1534/g3.118.200292
A Dense Linkage Map of Lake Victoria Cichlids Improved the Pundamilia Genome Assembly and Revealed a Major QTL for Sex-Determination
Philine G. D. Feulner, Julia Schwarzer, Marcel P. Haesler, Joana I. Meier, Ole Seehausen
G3: Genes, Genomes, Genetics July 2018 8: 2411-2420; https://doi.org/10.1534/g3.118.200207
Hybrid Sterility in Fish Caused by Mitotic Arrest of Primordial Germ Cells
Hiroyuki Yoshikawa, Dongdong Xu, Yasuko Ino, Tasuku Yoshino, Takao Hayashida, Junjie Wang, Ryosuke Yazawa, Goro Yoshizaki, Yutaka Takeuchi
Genetics June 2018 209: 507-521; https://doi.org/10.1534/genetics.118.300777
Identification of General Patterns of Sex-Biased Expression in Daphnia, a Genus with Environmental Sex Determination
Cécile Molinier, Céline M.O. Reisser, Peter Fields, Adeline Ségard, Yan Galimov, Christoph R. Haag
G3: Genes, Genomes, Genetics May 2018 8: 1523-1533; https://doi.org/10.1534/g3.118.200174
Dosage-Dependent Expression Variation Suppressed on the Drosophila Male X Chromosome
Hangnoh Lee, Dong-Yeon Cho, Damian Wojtowicz, Susan T. Harbison, Steven Russell, Brian Oliver, Teresa M. Przytycka
G3: Genes, Genomes, Genetics February 2018 8: 587-598; https://doi.org/10.1534/g3.117.300400
Long-Term Fragility of Y Chromosomes Is Dominated by Short-Term Resolution of Sexual Antagonism Open Access
Heath Blackmon, Yaniv Brandvain
Genetics December 2017 207: 1621-1629; https://doi.org/10.1534/genetics.117.300382
Distinct and Cooperative Roles of amh and dmrt1 in Self-Renewal and Differentiation of Male Germ Cells in Zebrafish
Qiaohong Lin, Jie Mei, Zhi Li, Xuemei Zhang, Li Zhou, Jian-Fang Gui
Genetics November 2017 207: 1007-1022; https://doi.org/10.1534/genetics.117.300274
Hill-Robertson Interference Reduces Genetic Diversity on a Young Plant Y-Chromosome
Josh Hough, Wei Wang, Spencer C. H. Barrett, Stephen I. Wright
Genetics October 2017 207: 685-695; https://doi.org/10.1534/genetics.117.300142
Control of a Novel Spermatocyte-Promoting Factor by the Male Germline Sex Determination Factor PHF7 of Drosophila melanogaster
Shu Yuan Yang, Yi-Chieh Chang, Yu Hsin Wan, Cale Whitworth, Ellen M. Baxter, Shekerah Primus, Haiwei Pi, Mark Van Doren
Genetics August 2017 206: 1939-1949; https://doi.org/10.1534/genetics.117.199935
Rapid Evolution of Ovarian-Biased Genes in the Yellow Fever Mosquito (Aedes aegypti)
Carrie A. Whittle, Cassandra G. Extavour
Genetics August 2017 206: 2119-2137; https://doi.org/10.1534/genetics.117.201343
Sex Chromosome Evolution, Heterochiasmy, and Physiological QTL in the Salmonid Brook Charr Salvelinus fontinalis
Ben J.G. Sutherland, Ciro Rico, Céline Audet, Louis Bernatchez
G3: Genes, Genomes, Genetics August 2017 7: 2749-2762; https://doi.org/10.1534/g3.117.040915
Comparative Genomics of the Ectomycorrhizal Sister Species Rhizopogon vinicolor and Rhizopogon vesiculosus (Basidiomycota: Boletales) Reveals a Divergence of the Mating Type B Locus
Alija Bajro Mujic, Alan Kuo, Andrew Tritt, Anna Lipzen, Cindy Chen, Jenifer Johnson, Aditi Sharma, Kerrie Barry, Igor V. Grigoriev, Joseph W. Spatafora
G3: Genes, Genomes, Genetics June 2017 7: 1775-1789; https://doi.org/10.1534/g3.117.039396
Revisiting Suppression of Interspecies Hybrid Male Lethality in Caenorhabditis Nematodes
Lauren E. Ryan, Eric S. Haag
G3: Genes, Genomes, Genetics April 2017 7: 1211-1214; https://doi.org/10.1534/g3.117.039479
To Break or Not To Break: Sex Chromosome Hemizygosity During Meiosis in Caenorhabditis
Mike V. Van, Braden J. Larson, JoAnne Engebrecht
Genetics November 2016 204: 999-1013; doi: 10.1534/genetics.116.194308
Untangling the Contributions of Sex-Specific Gene Regulation and X-Chromosome Dosage to Sex-Biased Gene Expression in Caenorhabditis elegans
Maxwell Kramer, Prashant Rao, Sevinc Ercan
Genetics September 2016 204: 355-369; doi: 10.1534/genetics.116.190298
Plasticity in the Meiotic Epigenetic Landscape of Sex Chromosomes in Caenorhabditis Species
Braden J. Larson, Mike V. Van, Taylor Nakayama, JoAnne Engebrecht
Genetics August 2016 203: 1641-1658; doi: 10.1534/genetics.116.191130
Extra Microchromosomes Play Male Determination Role in Polyploid Gibel Carp
Xi-Yin Li, Qi-Ya Zhang, Jun Zhang, Li Zhou, Zhi Li, Xiao-Juan Zhang, Da Wang, Jian-Fang Gui
Genetics July 2016 203: 1415-1424; doi: 10.1534/genetics.115.185843
Genetic Diversity on the Human X Chromosome Does Not Support a Strict Pseudoautosomal Boundary
Daniel J. Cotter, Sarah M. Brotman, Melissa A. Wilson Sayres
Genetics May 2016 203: 485-492; doi: 10.1534/genetics.114.172692
A Novel Candidate Gene for Temperature-Dependent Sex Determination in the Common Snapping Turtle
Anthony L. Schroeder, Kelsey J. Metzger, Alexandra Miller, Turk Rhen
Genetics May 2016 203: 557-571; doi: 10.1534/genetics.115.182840
Coordination of Recombination with Meiotic Progression in the Caenorhabditis elegans Germline by KIN-18, a TAO Kinase That Regulates the Timing of MPK-1 Signaling
Yizhi Yin, Sean Donlevy, Sarit Smolikove
Genetics January 2016 202: 45-59; doi: 10.1534/genetics.115.177295
An Unusual Role for doublesex in Sex Determination in the Dipteran Sciara
María Fernanda Ruiz, Mercedes Alvarez, José M. Eirín-López, Francesca Sarno, Leonor Kremer, José L. Barbero, Lucas Sánchez
Genetics August 2015 200: 1181-1199; doi: 10.1534/genetics.115.177972
Wild Sex in Zebrafish: Loss of the Natural Sex Determinant in Domesticated Strains
Catherine A. Wilson, Samantha K. High, Braedan M. McCluskey, Angel Amores, Yi-lin Yan, Tom A. Titus, Jennifer L. Anderson, Peter Batzel, Michael J. Carvan, Manfred Schartl, John H. Postlethwait
Genetics November 2014 198: 1291-1308; doi: 10.1534/genetics.114.169284
A Genome-Wide Survey of Sexually Dimorphic Expression of Drosophila miRNAs Identifies the Steroid Hormone-Induced miRNA let-7 as a Regulator of Sexual Identity
Delphine Fagegaltier, Annekatrin König, Assaf Gordon, Eric C. Lai, Thomas R. Gingeras, Gregory J. Hannon, Halyna R. Shcherbata
Genetics October 2014 198: 647-668; doi: 10.1534/genetics.114.169268
Regulation of Sex Determination in Mice by a Non-coding Genomic Region
Valerie A. Arboleda, Alice Fleming, Hayk Barseghyan, Emmanuèle Délot, Janet S. Sinsheimer, Eric Vilain
Genetics July 2014 197: 885-897; doi: 10.1534/genetics.113.160259
Sex-Biased Gene Expression and Evolution of the X Chromosome in Nematodes
Sarah Elizabeth Albritton, Anna-Lena Kranz, Prashant Rao, Maxwell Kramer, Christoph Dieterich, Sevinç Ercan
Genetics July 2014 197: 865-883; doi: 10.1534/genetics.114.163311
Estimating Tempo and Mode of Y Chromosome Turnover: Explaining Y Chromosome Loss With the Fragile Y Hypothesis
Heath Blackmon, Jeffery P. Demuth
Genetics June 2014 197: 561-572; doi: 10.1534/genetics.114.164269
Signatures of Sex-Antagonistic Selection on Recombining Sex Chromosomes
Mark Kirkpatrick, Rafael F. Guerrero
Genetics June 2014 197: 531-541; doi: 10.1534/genetics.113.156026
Pseudosynapsis and Decreased Stringency of Meiotic Repair Pathway Choice on the Hemizygous Sex Chromosome of Caenorhabditis elegans Males
Paula M. Checchi, Katherine S. Lawrence, Mike V. Van, Braden J. Larson, JoAnne Engebrecht
Genetics June 2014 197: 543-560; doi: 10.1534/genetics.114.164152
The Genetics of Sex: Exploring Differences
Michelle N. Arbeitman, Artyom Kopp, Mark L. Siegal, Mark Van Doren
Genetics June 2014 197: 527-529; doi: 10.1534/genetics.114.165456
Neurons That Underlie Drosophila melanogaster Reproductive Behaviors: Detection of a Large Male-Bias in Gene Expression in fruitless-Expressing Neurons
Nicole R. Newell, Felicia N. New, Justin E. Dalton, Lauren M. McIntyre, Michelle N. Arbeitman
G3: Genes, Genomes, Genetics August 2016 6: 2455-2465; doi: 10.1534/g3.115.019265
Sex Differences in Drosophila Somatic Gene Expression: Variation and Regulation by doublesex
Michelle N. Arbeitman, Felicia N. New, Justin M. Fear, Tiffany S. Howard, Justin E. Dalton, Rita M. Graze
G3: Genes, Genomes, Genetics July 2016 6: 1799-1808; doi: 10.1534/g3.116.027961
Sequence of the Gonium pectorale Mating Locus Reveals a Complex and Dynamic History of Changes in Volvocine Algal Mating Haplotypes
Takashi Hamaji, Yuko Mogi, Patrick J. Ferris, Toshiyuki Mori, Shinya Miyagishima, Yukihiro Kabeya, Yoshiki Nishimura, Atsushi Toyoda, Hideki Noguchi, Asao Fujiyama, Bradley J. S. C. Olson, Tara N. Marriage, Ichiro Nishii, James G. Umen, Hisayoshi Nozaki
G3: Genes, Genomes, Genetics May 2016 6: 1179-1189; doi: 10.1534/g3.115.026229
A Genetic Map for the Only Self-Fertilizing Vertebrate
Akira Kanamori, Yosuke Sugita, Yasufumi Yuasa, Takamasa Suzuki, Kouichi Kawamura, Yoshinobu Uno, Katsuyasu Kamimura, Yoichi Matsuda, Catherine A. Wilson, Angel Amores, John H. Postlethwait, Koushirou Suga, Yoshitaka Sakakura
G3: Genes, Genomes, Genetics April 2016 6: 1095-1106; doi: 10.1534/g3.115.022699
Cell-Specific mRNA Profiling of the Caenorhabditis elegans Somatic Gonadal Precursor Cells Identifies Suites of Sex-Biased and Gonad-Enriched Transcripts
Mary B. Kroetz, David Zarkower
G3: Genes, Genomes, Genetics December 2015 5: 2831-2841; doi: 10.1534/g3.115.022517
Turnover of Sex Chromosomes in Celebensis Group Medaka Fishes
Taijun Myosho, Yusuke Takehana, Satoshi Hamaguchi, Mitsuru Sakaizumi
G3: Genes, Genomes, Genetics December 2015 5: 2685-2691; doi: 10.1534/g3.115.021543
Genomic Instability of the Sex-Determining Locus in Atlantic Salmon (Salmo salar)
Krzysztof P. Lubieniecki, Song Lin, Emily I. Cabana, Jieying Li, Yvonne Y. Y. Lai, William S. Davidson
G3: Genes, Genomes, Genetics November 2015 5: 2513-2522; doi: 10.1534/g3.115.020115
Fine Mapping and Evolution of the Major Sex Determining Region in Turbot (Scophthalmus maximus)
Xoana Taboada, Miguel Hermida, Belén G. Pardo, Manuel Vera, Francesc Piferrer, Ana Viñas, Carmen Bouza, Paulino Martínez
G3: Genes, Genomes, Genetics October 2014 4: 1871-1880; doi: 10.1534/g3.114.012328
Evidence of Hermaphroditism and Sex Ratio Distortion in the Fungal Feeding Nematode Bursaphelenchus okinawaensis
Ryoji Shinya, Koichi Hasegawa, Anthony Chen, Natsumi Kanzaki, Paul W. Sternberg
G3: Genes, Genomes, Genetics October 2014 4: 1907-1917; doi: 10.1534/g3.114.012385
An X-Linked Sex Ratio Distorter in Drosophila simulans That Kills or Incapacitates Both Noncarrier Sperm and Sons
William R. Rice
G3: Genes, Genomes, Genetics October 2014 4: 1837-1848; doi: 10.1534/g3.114.013292
Molecular Characterization of a Heterothallic Mating System in Pseudogymnoascus destructans, the Fungus Causing White-Nose Syndrome of Bats
Jonathan M. Palmer, Alena Kubatova, Alena Novakova, Andrew M. Minnis, Miroslav Kolarik, Daniel L. Lindner
G3: Genes, Genomes, Genetics September 2014 4: 1755-1763; doi: 10.1534/g3.114.012641
A New Dataset of Spermatogenic vs. Oogenic Transcriptomes in the Nematode Caenorhabditis elegans
Marco A. Ortiz, Daniel Noble, Elena P. Sorokin, Judith Kimble
G3: Genes, Genomes, Genetics September 2014 4: 1765-1772; doi: 10.1534/g3.114.012351
Self-Incompatibility in Brassicaceae: Identification and Characterization of SRK-Like Sequences Linked to the S-Locus in the Tribe Biscutelleae
Jean-Baptiste Leducq, Célia C Gosset, Rita Gries, Kevin Calin, Éric Schmitt, Vincent Castric, Xavier Vekemans
G3: Genes, Genomes, Genetics June 2014 4: 983-992; doi: 10.1534/g3.114.010843
Sex-Determination System in the Diploid Yeast Zygosaccharomyces sapae
Lisa Solieri, Tikam Chand Dakal, Paolo Giudici, Stefano Cassanelli
G3: Genes, Genomes, Genetics June 2014 4: 1011-1025; doi: 10.1534/g3.114.010405
Transcriptomes and Proteomes Define Gene Expression Progression in Pre-meiotic Maize Anthers
Han Zhang, Rachel L. Egger, Timothy Kelliher, Darren Morrow, John Fernandes, Guo-Ling Nan, Virginia Walbot
G3: Genes, Genomes, Genetics June 2014 4: 993-1010; doi: 10.1534/g3.113.009738