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The Sleep Inbred Panel, a Collection of Inbred Drosophila melanogaster with Extreme Long and Short Sleep Duration

View ORCID ProfileYazmin L. Serrano Negron, View ORCID ProfileNancy F. Hansen and View ORCID ProfileSusan T. Harbison
G3: Genes, Genomes, Genetics September 1, 2018 vol. 8 no. 9 2865-2873; https://doi.org/10.1534/g3.118.200503
Yazmin L. Serrano Negron
Laboratory of Systems Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD
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  • ORCID record for Yazmin L. Serrano Negron
Nancy F. Hansen
Comparative Genomics Analysis Unit, National Human Genome Research Institute, National Institutes of Health, Rockville, MD
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  • ORCID record for Nancy F. Hansen
Susan T. Harbison
Laboratory of Systems Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD
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  • ORCID record for Susan T. Harbison
  • For correspondence: susan.harbison@nih.gov
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Abstract

Understanding how genomic variation causes differences in observable phenotypes remains a major challenge in biology. It is difficult to trace the sequence of events originating from genomic variants to changes in transcriptional responses or protein modifications. Ideally, one would conduct experiments with individuals that are at either extreme of the trait of interest, but such resources are often not available. Further, advances in genome editing will enable testing of candidate polymorphisms individually and in combination. Here we have created a resource for the study of sleep with 39 inbred lines of Drosophila—the Sleep Inbred Panel (SIP). SIP lines have stable long- and short-sleeping phenotypes developed from naturally occurring polymorphisms. These lines are fully sequenced, enabling more accurate targeting for genome editing and transgenic constructs. This panel facilitates the study of intermediate transcriptional and proteomic correlates of sleep, and supports genome editing studies to verify polymorphisms associated with sleep duration.

  • sleep
  • Drosophila melanogaster
  • whole-genome sequence
  • Received January 4, 2018.
  • Accepted July 4, 2018.
  • Copyright © 2018 Negron et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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PUBLICATION INFORMATION

Volume 8 Issue 9, September 2018

G3: Genes|Genomes|Genetics: 8 (9)

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The Sleep Inbred Panel, a Collection of Inbred Drosophila melanogaster with Extreme Long and Short Sleep Duration

View ORCID ProfileYazmin L. Serrano Negron, View ORCID ProfileNancy F. Hansen and View ORCID ProfileSusan T. Harbison
G3: Genes, Genomes, Genetics September 1, 2018 vol. 8 no. 9 2865-2873; https://doi.org/10.1534/g3.118.200503
Yazmin L. Serrano Negron
Laboratory of Systems Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Yazmin L. Serrano Negron
Nancy F. Hansen
Comparative Genomics Analysis Unit, National Human Genome Research Institute, National Institutes of Health, Rockville, MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Nancy F. Hansen
Susan T. Harbison
Laboratory of Systems Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Susan T. Harbison
  • For correspondence: susan.harbison@nih.gov
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Citation

The Sleep Inbred Panel, a Collection of Inbred Drosophila melanogaster with Extreme Long and Short Sleep Duration

View ORCID ProfileYazmin L. Serrano Negron, View ORCID ProfileNancy F. Hansen and View ORCID ProfileSusan T. Harbison
G3: Genes, Genomes, Genetics September 1, 2018 vol. 8 no. 9 2865-2873; https://doi.org/10.1534/g3.118.200503
Yazmin L. Serrano Negron
Laboratory of Systems Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Yazmin L. Serrano Negron
Nancy F. Hansen
Comparative Genomics Analysis Unit, National Human Genome Research Institute, National Institutes of Health, Rockville, MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Nancy F. Hansen
Susan T. Harbison
Laboratory of Systems Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Susan T. Harbison
  • For correspondence: susan.harbison@nih.gov

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