Table 1 Aspergillus fumigatus phosphatase gene families
FamilyaSubfamilybClass/DomaincA. fumigatus ID GenesA. fumigatus ProteinsEffect of the Deletion on A. fumigatusA. nidulans GenesS. cerevisiae Protein
S/TPPPPP2AcAfu5g12010PphAViableAN0103Pph3p
S/TPPPPP2AcAfu5g11370PpgANDdAN0164Ppg1p
S/TPPPPP2AcAfu1g04950GlcALethalAN0410 bimGGlc7p
S/TPPPPP2AcAfu6g11470SitAViableAN0504 sitASit4P
S/TPPPPP2AcAfu2g03950PpzAViableAN3793Ppz1p
S/TPPPPP2AcAfu6g10830PphBLethalAN6391 pphAPph21p
S/TPPPPP2AcAfu5g06700PptAViableAN10281Ppt1p
S/TPPPPP2BcAfu5g09360CalA/CnaAViableAN8820 cnaACmp2p
S/TPPMPP2CcAfu1g15800PtcAViableAN0914Ptc6p
S/TPPMPP2CcAfu1g09280PtcBViableAN1358Ptc2p
S/TPPMPP2CcAfu8g04580PpmAViableAN1467−/−
S/TPPMPP2CcAfu5g13740,PtcD,Both viableAN2472Ptc2p
Afu2g03890PtcE
S/TPPMPP2CcAfu1g06860PtcFViableAN5722Ptc5p
S/TPPMPP2CcAfu5g13340PtcGViableAN6892Ptc1p
S/TPPMPP2CcAfu4g00720PtcHViableAN2472Ptc1p
S/TAsp-basedHADAfu1g09460NemAViableAN1343Nem1p
S/TAsp-basedHADAfu3g11410FcpALethalAN2902Fcp1p
S/TAsp-basedHADAfu1g04790PsrAViableAN10077Psr1p
PTPDual-specificityDSPcAfu5g11690PpsAViableAN0129−/−
PTPDual-specificityDSPcAfu4g07080DspCLethalAN4419−/−
PTPDual-specificityDSPcAfu2g02760DspDViableAN4544−/−
PTPDual-specificityDSPcAfu3g12250CdcAViableAN5057Cdc14p
PTPDual-specificityDSPcAfu1g13040DspAViableAN10138−/−
PTPDual-specificityDSPcAfu1g03540DspBViableAN4057−/−
PTPClassicalPTPcAfu3g10970PtpBViableAN4896Ptp1p
PTPClassicalPTPcAfu4g04710PypAViableAN6982Ptp2p
PTPLMW-PTPLMWPcAfu2g01880LtpAViableAN10570Ltp1p/Yvh1p
SSU72SSU72SSU72Afu2g03760SsuANDdAN3810Ssu72p
PTPCDC-25 typeCDC25Afu6g08200NimTNDdAN3941 nimT−/−
PTPY-fosfataseAfu4g07000YphAViableAN4426−/−
PTPY-fosfatase 3Afu6g06650PtyAViableAN5767Ptc7p
  • a Family abbreviations: S/T, serine/threonine; PTP, protein tyrosine phosphatase.

  • b Subfamily abbreviations: PPP, phosphoprotein phosphatase; PPM, Mg2+ or Mn2+-dependent protein phosphatase; Asp-based, aspartate-based phosphatase; LMW-PTP, low-molecular-weight protein tyrosine phosphatase; CDC25 type, cell division cycle 25 type; SSU72, C-terminal domain RNA Pol II phosphatase.

  • c Class/domain abbreviations: PP2Ac, protein phosphatase 2 A catalytic subunit; PP2Bc, protein phosphatase 2B catalytic subunit; PP2Cc, protein phosphatase 2C catalytic subunit; HAD, haloacid dehalogenase; PTPc, protein tyrosine phosphatase catalytic subunit; DSPc, dual-specificity phosphatase catalytic subunit; LMWPc, low-molecular-weight phosphatase catalytic subunit; CDC25, cell division cycle; SSU72, C-terminal domain RNA polymerase II phosphatase; Y-phosphatase 3, tyrosine phosphatase 3.

  • d Not determined.