Table 2 Validated DLBCL subtype signature genes
Gene NameGene DescriptionGCB Read CountsABC Read CountsFold ChangeFDR
ABC signature
 BCL2B-cell CLL/lymphoma 24,599.5222,162.494.824.90E-05
 CCND2Cyclin D231.203692.67118.601.56E-18
 CFLARCASP8 and FADD-like apoptosis regulator460.636463.3714.035.52E-09
 FOXP1forkhead box P11202.376588.565.461.13E-04
 IRF4Interferon regulatory factor 4976.0121,475.2822.012.43E-14
 NFKBIZNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta962.348119.558.465.63E-06
GCB signature
 BCL6B-cell CLL/lymphoma 615,105.685124.250.341.94E-02
 MAPK10Mitogen-activated protein kinase 101473.1057.420.044.45E-05
 MME (CD10)Membrane metallo-endopeptidase6163.64663.160.116.01E-05
 MYBL1v-myb myeloblastosis viral oncogene homolog (avian)-like 12932.21661.390.234.99E-02
  • DLBCL, diffuse large B-cell lymphoma; GCB, germinal center B-cell-like; ABC, activated B-cell-like; FDR, false-discovery rate; CLL, chronic lymphocytic leukemia.