Table 3 GO term and functional classification enrichment analysis using DAVID for gene families that are contracted in the Drosophila suzukii genome as compared to other Drosophila species
Annotation ClusterEnrichment ScoreCategoryaTermbCountcPGene Families: Representative Gene Symbolsd
A. Comparison to 14 Drosophila genomes
13.02GOTERM CCGO:0000786 nucleosome58.14E−06His2B, His2Av, His1, His4r, His3.3A
SwissProt PIRAcetylation52.48E−05His2Av, Adh, Cam, His4r, His3.3A
22.59SwissProt PIRHydrolase264.48E−06CG1637, CG31821, S-Lap7, CG9449, Ace, CG30049, CG5731, Ance, PGRP-SA, CG14022, CG9391, ApepP, primo-2, CG14034, SPE, cathD, kraken, mag, CG2680, CG42264, CG31272, gd, LysC, Mdr49, CG6465, sda
GOTERM MFGO:0008233 peptidase activity122.21E−03CG31821, CG30049, ApepP, CG42264, S-Lap7, gd, SPE, CG6465, cathD, Ance, sda, PGRP-SA
32.54SwissProt PIRDisulfide bond91.56E−03crq, Adk2, gd, LysC, C1GalTA, Ace, CG5210, Ance, PGRP-SA
SwissProt PIRGlycoprotein122.31E−03PGRP-LE, crq, Orct2, Gr64a, pip, gd, Mdr49, C1GalTA, ninaG, Ace, CG5210, Ance
42.3GOTERM MFGO:0008238 exopeptidase activity63.74E−04CG31821, ApepP, CG42264, S-Lap7, Ance, sda
SwissProt PIRCarboxypeptidase31.40E−02CG31821, CG42264, Ance
52.24SwissProt PIRAminopeptidase31.62E−02ApepP, S-Lap7, sda
62.03SwissProt PIRsignal114.87E−03Acp1, Cpr47Eg, Acp53Ea, gd, LysC, ninaG, rumi, Ace, CG5210, Ance, PGRP-SA
GOTERM CCGO:0005576 extracellular region122.79E−02PGRP-LE, Cpr47Eg, obst-A, Acp53Ea, CG6933, gd, ninaG, CG5210, Ance, PGRP-SA, Spn27A, CG17739
71.83GOTERM BPGO:0008063 Toll signaling pathway55.04E−04pip, gd, SPE, PGRP-SA, Spn27A
81.55GOTERM BPGO:0006026 aminoglycan catabolic process31.50E−02PGRP-LE, CG5210, PGRP-SA
GOTERM BPGO:0006022 aminoglycan metabolic process54.30E−02PGRP-LE, obst-A, CG6933, CG5210, PGRP-SA
91.55GOTERM BPGO:0006952 defense response73.29E−03PGRP-LE, crq, Tak1, LysC, SPE, PGRP-SA, Spn27A
GOTERM BPGO:0006955 immune response73.66E−03PGRP-LE, crq, Tak1, LysC, SPE, PGRP-SA, Spn27A
101.32SwissProt PIRMembrane163.33E−02C1GalTA, eca, Ace, rost, Cyp6g1, crq, Orct2, Tret1-1, Gr64a, Gr93c, pip, Drip, Mdr49, ppk19, GluRIIA, Tsp42Ee
SwissProt PIRTransmembrane153.61E−02C1GalTA, eca, rost, crq, Orct2, Tret1-1, Gr64a, Gr93c, pip, Drip, Mdr49, ppk19, GluRIIA, Tsp42Ee, CG32053
111.23SwissProt PIRSynapse34.14E−02Snap25, Ace, GluRIIA
B. Comparison to D. ananassae, D. persimilis, D. pseudoobscura, D. willistoni, D. grimshawi, D. mojavensis, and D. virulis
12.61GOTERM CCGO:0000786 nucleosome52.00E−05His2B, His2Av, His1, His4r, His3.3A
GOTERM BPGO:0034728 nucleosome organization62.59E−04His2B, His2Av, His1, Nipped-A, His4r, His3.3A
SwissProt PIRacetylation41.38E−03His2Av, Adh, His4r, His3.3A
22.12GOTERM BPGO:0006508 proteolysis151.10E−03lwr, CG31821, S-Lap7, Roc1a, SPE, cathD, CG11864, CG30049, CG42264, CG32486, Nedd8, Prosbeta3, gd, CG6465, Ance
GOTERM MFGO:0008233 peptidase activity133.84E−03CG31821, ApepP, S-Lap7, SPE, cathD, CG11864, CG30049, CG42264, Prosbeta3, gd, CG6465, PGRP-SA, Ance
32.09SwissProt PIRGlycoprotein141.64E−03PGRP-LE, CG4928, C1GalTA, Ace, crq, Orct2, Gr64a, pip, gd, Mdr49, ninaG, prominin-like, CG5210, Ance
SwissProt PIRMembrane185.62E−02CG4928, C1GalTA, eca, Ace, rost, Cyp6g1, crq, Orct2, Tret1-1, Gr64a, Gr93c, pip, Drip, Mdr49, prominin-like, ppk19, GluRIIA, Tsp42Ee
41.89SwissProt PIRSignal128.54E−03Acp1, Cpr47Eg, Amyrel, gd, LysC, ninaG, rumi, Dpt, Ace, CG5210, Ance, PGRP-SA
GOTERM CCGO:0005576 extracellular region135.70E−02PGRP-LE, Cpr47Eg, Amyrel, CG17575, Dpt, obst-A, gd, ninaG, CG5210, Muc26B, PGRP-SA, Ance, CG17739
51.76GOTERM MFGO:0008238 exopeptidase activity57.22E−03CG31821, ApepP, CG42264, S-Lap7, Ance
SwissProt PIRcarboxypeptidase32.15E−02CG31821, CG42264, Ance
61.49GOTERM BPGO:0006955 immune response82.87E−03lwr, PGRP-LE, crq, Tak1, LysC, SPE, Dpt, PGRP-SA
GOTERM BPGO:0042742 defense response to bacterium58.54E−03PGRP-LE, LysC, SPE, Dpt, PGRP-SA
71.36GOTERM BPGO:0006026 aminoglycan catabolic process32.39E−02PGRP-LE, CG5210, PGRP-SA
GOTERM BPGO:0009057 macromolecule catabolic process85.95E−02lwr, PGRP-LE, Prosbeta3, Nedd8, CG32486, Roc1a, CG5210, PGRP-SA
C. Comparison to the Melanogaster subgroupe
12.76GOTERM BPGO:0008063 Toll signaling pathway69.04E−05IM10, pip, gd, SPE, PGRP-SA, Spn27A
GOTERM BPGO:0006952 defense response94.43E−04PGRP-LE, crq, IM10, Tak1, LysC, SPE, IM2, PGRP-SA, Spn27A
22.73GOTERM CCGO:0000786 nucleosome51.78E−05His2B, His2Av, His1, His4r, His3.3A
SwissProt PIRAcetylation56.19E−05His2Av, Adh, Cam, His4r, His3.3A
32.61SwissProt PIRSignal141.07E−03Acp1, Cpr47Eg, IM10, Acp53Ea, Ace, gd, LysC, rumi, ninaG, IM2, CG5210, PGRP-SA, mth, Ance
GOTERM CCGO:0005576 extracellular region159.25E−03PGRP-LE, Cpr47Eg, IM10, CheB42a, Acp53Ea, Spn27A, CG6933, gd, ninaG, IM2, CG5210, Muc26B, PGRP-SA, Ance, CG17739
42.45GOTERM CCDisulfide bond114.43E−04crq, Adk2, gd, LysC, C1GalTA, IM2, Ace, CG5210, mth, Ance, PGRP-SA
GOTERM CCGlycoprotein141.74E−03PGRP-LE, IM10, C1GalTA, Ace, crq, Orct2, Gr64a, pip, gd, Mdr49, ninaG, CG5210, mth, Ance
52.23GOTERM MFGO:0008238 exopeptidase activity67.73E−04CG31821, ApepP, CG42264, S-Lap7, Ance, sda
GOTERM MFGO:0008233 peptidase activity132.58E−03CG31821, ApepP, S-Lap7, SPE, CG42370, cathD, CG30049, CG42264, gd, CG6465, PGRP-SA, sda, Ance
62.09SwissProt PIRcarboxypeptidase32.18E−02CG31821, CG42264, Ance
72.03SwissProt PIRAminopeptidase32.51E−02ApepP, S-Lap7, sda
81.89SwissProt PIRTransmembrane221.60E−03CG13796, Or65a, C1GalTA, eca, Gr22f, rost, crq, Orct2, Tret1-1, Gr64a, Gr93c, pip, CG32301, Drip, Mdr49, sesB, mth, ppk19, CG7255, CG32053, Tsp42Ee, GluRIIA
SwissProt PIRMembrane218.80E−03Or65a, C1GalTA, Gr22f, eca, Ace, rost, Cyp6g1, crq, Orct2, Tret1-1, Gr64a, Gr93c, pip, CG32301, Drip, Mdr49, sesB, mth, ppk19, Tsp42Ee, GluRIIA
91.43GOTERM BPGO:0006026 aminoglycan catabolic process32.29E−02PGRP-LE, CG5210, PGRP-SA
101.41GOTERM BPGO:0008219∼cell death89.69E−03eIF-4E, Cyt-c-d, crq, qkr58E-3, Eig71Ej, Tak1, LysC, cathD
111.39GOTERM BPGO:0045087 innate immune response75.86E−04PGRP-LE, IM10, Tak1, SPE, IM2, PGRP-SA, Spn27A
GOTERM BPGO:0002786 regulation of antibacterial peptide production33.96E−02Tak1, SPE, PGRP-SA
  • CC, cellular component; PIR, protein information resource; MF, molecular function; BP, biological process.

  • a Categories used in DAVID analysis include GO subontologies for BP, MF, and CC, as well as keywords from SwissProt PIR and protein domains from the INTERPRO database.

  • b Only representative terms with highly significant P values are shown for each annotation cluster. See Table S7, Table S8, Table S9, Table S10, Table S11, and Table S12 for complete lists.

  • c Count represents the number of gene families.

  • d Gene symbol for representative, most highly annotated member of each gene family is shown. All annotations shown here are from D. melanogaster.

  • e D. simulans, D. sechellia, D. melanogaster, D. yakuba, and D. erecta.