Table 7 Akashi’s test for the conservation of preferred codons between species
GroupNo. of GenesM-H Χ2ORaP-valueP(Better Codon Set)b
022531.461.2871.02e-08< 0.001
159238.461.1632.70e-100.005
274436.251.0988.69e-100.007
356224.081.1374.61e-10< 0.001
4828123.841.2134.59e-290.024
All2349247.771.1933.98e-560.036
  • OR, odds ratio.

  • a Woolf test on homogeneity of ORs (Woolf 1955) shows significant three-way association for all groups.

  • b P(Better Codon Set) is the fraction of 1000 randomly generated alternate preferred synonymous codon sets having a stronger association with conserved codons than the observed preferred set (see Materials and Methods).